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Depakote ( Divalproex)
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Depakote, also known as Divalproex is useful in controlling certain types of seizures in properly treating epilepsy.
Depakote 500 mg (Normal Dosage)

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30 pills $62.15 $1.57

60 pills $107.29 $1.36

90 pills $138.83 $1.17 Save

Depakote 250 mg (Low Dosage)

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30 pills $36.90 $0.93

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Drug Uses

Depakote is known for controlling certain types of seizures especially in the treatment of epilepsy. It can also be made useful in treating the manic phase of bipolar disorders or manic-depressive illness and can also be used for preventing migraine headaches.


Medication must always be taken as advised by your medical practitioner/physician. If you are unsure, then please contact your physician for precise instructions. On the other hand, the medicine label usually contains dosage instructions which also may be followed.

Depakote may be taken with a meal or without a meal to prevent stomach problems. Do not break or chew the tablet, just swallow it down.

A full glass of water when taken with Depakote always ensures better absorption.

Medications are prescribed according to a dosage schedule which must be completed in order to reap the benefits of the treatment. Lapsed schedules render Depakote ineffective. So, never stop in between unless advised by your physician.

One of the best ways to ensure that you do not miss out on a dose is to maintain a fixed regime for consuming Depakote each day.

Drug Class and Mechanism

Depakote being an anticonvulsant reduces and prevents the number of seizures. It seeks to control the abnormal activity of the nerve impulses in the brain as well as in the central nervous system.

Missed Dose

You must maintain a schedule for taking the medicine at the same time each day so that you do not miss out on any doses. But, in the advent of a missed dose, take it as soon as you remember so that you can compensate for the loss of the dose.

But, then you may need to adjust your remaining doses accordingly. And if it is almost time for the next dose, then please skip the missed dose and continue with the normal schedule.

Never try to compensate for the missed dose by taking a double dose together. It may cause adverse effects.


Depakote must be stored at a cool and dark place that prevents it from direct exposure to sunlight. It should also be protected from kids and pets. You can store it at room temperature, of around 30 degrees C.

If you are allergic to any ingredient in Depakote (you may check medicine label) then please do not use it without consulting your doctor.

You must also avoid using Depakote if you have conditions like history of liver conditions and have low levels of the enzyme ornithine carbamoyltransferase, or even are suffering from a urea cycle disorder.

Ensure that your doctor is aware of your past and current medical history before you start any new treatment or medication. This must include any and all diseases that you have suffered /suffer from, all subscription and over the counter medication that you are taking, including vitamins and herbal supplements. This will help avoid a possible interaction or allergy.

In some cases, the medication might be altered or require special attention if you suffer from conditions. If your pancreas inflate, then it is advisable for you to stop the usage of Depakote and also to meet your medical practitioner as soon as possible.

Depakote is known to make some people dizzy or drowsy. It is advisable to avoid tasks that require mental alertness for example, driving, handling heavy equipment or machinery etc.

Diabetic patients who are taking Depakote must remember that some tests for urine ketones may go wrong. So it is advisable to speak to your doctor before you try and change your diet or the dosage of your diabetes medicine.

Certain laboratory tests may be made mandatory while you are using Depakote. These tests include blood cell counts as well as liver function tests and are conducted to analyze your progress to treatment and guage the degree to which side effects are being experienced. You must never miss out on any such lab tests.

Your lab technician or doctor must be informed that you are taking Depakote before you undergo any lab tests or emergency surgical procedures.

Pregnancy Info

If you are planning to have a baby or are pregnant already then you must seek advice from your doctor before using Depakote. Discuss the effects and possible risks that Depakote usage may have on the unborn baby.

If you are breast feeding your child, then too seek medical advice before using Depakote. Some drugs may be excreted in the breast milk and may harm the baby.
Side Effects

It is common to experience some temporary and mildly annoying side effects as the body adjusts to the new drug. These rarely require any special medical attention and usually fade away automatically.

These include change in appetite, diarrhea, constipation, dizziness, hair loss, drowsiness, headache, nausea, indigestion, stomach pain, weight changes, and trouble in sleeping and also vomiting.

But, if they refuse to fade away or become bothersome, then seek medical attention immediately.

On the other hand, if you experience serious side effects like severe allergic reactions leading to a difficulty in breathing along with swelling of various parts of the body, tightness in the chest, abdominal cramps, rash, abnormal thinking, itching, change in menstrual period, confusion, changes in mood and behavior, dark urine, chest pain, difficulty in speaking, irregular heartbeats, difficulty urinating, extreme tiredness, fever, involuntary movements of the body parts, general body discomfort, hearing loss, hallucinations, joint pain, loss of appetite and coordination, lack of energy, loss of seizure control, nosebleed, memory loss, pounding of the chest, vomiting, severe nausea, stomach pain, tremor, sore throat, unusual bleeding and weakness along with vision changes and also yellowing of skin and eyes.

Seek immediate medical attention if you notice any of these side effects.

In some cases, you may also notice side effects that are not listed here. In such cases, seek medical attention.
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