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Differin ( Adapalene)
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differin (Adapalene) is a retinoid-like compound, used to treat acne
Differin 15 gr

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This medicine is a retinoid-like compound, used to treat acne.
However, your doctor may also prescribe differin for other conditions if found appropriate.

How to use differin

The ideal way to use differin is to follow the instructions of your doctor. An alternative way is to check the medicine label for dosage instructions.

Before applying differin, wash the affected area with a mild soap and gently dry. Apply a thin film of medicine to the affected and surrounding area. Rub in gently

You must not stop taking differin without consulting your doctor even if you attain relief after a short while post starting treatment.

Drug Class and Mechanism

Adapalene is main ingridient of differin. Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown. Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients

Missed Dose

It is important that you maintain a strict schedule for taking differin to ensure that you do not miss any doses. But if you do, then you may take it as soon as you remember provided that you space out the next dosage accordingly.


Store differin at room temperature. Ensure that you protect it from direct exposure to heat/moisture/light and from the reach of children and pets.
Do not get this medicine in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time.
Do not use other medicines on your skin without first discussing it with your doctor.
While you are using this medicine, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine.
Do not use differin if you are allergic to any of the ingredients in it (read medicine label if unsure).

If you are pregnant or have plans for a pregnancy, then consult your doctor before using differin as differin may harm your fetus.

If you are breast feeding then please maintain caution as it is unknown whether differin is passed into the breast milk. So please consult your doctor prior to using it.

differin is known to make the skin more sensitive to sunlight. So excessive sun exposure without using protection (sunscreen or protective clothing) or exposure to tanning booths and sunlamps must be avoided.
Do not apply this medicine to sunburned skin
Most drugs have some kind of side effects associated with them. However, most people do not experience them at all or experience just mild side effects which subside as the body adjusts to the medicine.

Some of the mild but common side effects that the patient may experience on their skin while using differin are redness, itching, dryness, peeling, stinging, or a feeling of warmth.

However, please contact your doctor if these side effects do not go away after a while or start bothering you.

On the other hand, differin may also cause some severe side effects like blistering, crusting, swelling, or excessive redness or peeling of your skin.

Please seek medical attention immediately if you experience any of these severe side effects.
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