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Sinemet ( Carbidopa/Levodopa)
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Sinemet, also known as Carbidopa or Levodopa is used in the treatment of Parkinsonís disease. It is used for helping control parkinsonís and its related symptoms.
Sinemet 300 mg (Normal Dosage)

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Sinemet 125 mg (Low Dosage)

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Sinemet 110 mg (Extra Low Dosage)

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Drug Uses

Sinemet, also known as Carbidopa or Levodopa is used in the treatment of Parkinsonís disease. It is used for helping control parkinsonís and its related symptoms.
It can also be made useful for a number of other conditions as and when prescribed by your medical practitioner.


Medication must always be taken as advised by your medical practitioner/physician. If you are unsure, then please contact your physician for precise instructions. On the other hand, the medicine label usually contains dosage instructions which also may be followed.

Sinemet may be taken with a meal or without a meal to prevent stomach problems.

A full glass of water when taken with Sinemet always ensures better absorption.

Medications are prescribed according to a dosage schedule which must be completed in order to reap the benefits of the treatment. Lapsed schedules render Sinemet ineffective. So, never stop in between unless advised by your physician. If you are into iron salts, then make sure there is a gap of at least 2 hours between both the medications.

One of the best ways to ensure that you do not miss out on a dose is to maintain a fixed regime for consuming Sinemet each day.

Drug Class and Mechanism

Sinemet being a combination of antidyskinetic combination helps levodopa to reach the human brain. This levodopa is first transformed by the body as well as the brain into a matter that decreases tremors and some of the other symptoms of Parkinson disease. Carbidopa helps levodopa to reach the brain.

Missed Dose

You must maintain a schedule for taking the medicine at the same time each day so that you do not miss out on any doses. But, in the advent of a missed dose, take it as soon as you remember so that you can compensate for the loss of the dose.

But, then you may need to adjust your remaining doses accordingly. And if it is almost time for the next dose, then please skip the missed dose and continue with the normal schedule.

Never try to compensate for the missed dose by taking a double dose together. It may cause adverse effects.


Sinemet must be stored at a cool and dark place that prevents it from direct exposure to sunlight. It should also be protected from kids and pets. You can store it at room temperature preferably between 20 to 25 degrees C.

If you are allergic to any ingredient in Sinemet (you may check medicine label) then please do not use it without consulting your doctor.

You must also avoid using Sinemet if you have conditions like narrow-angle glaucoma, skin cancer, undiagnosed skin growths, or a history of skin cancer or if you are into MAO or monoamine oxidas inhibitor and have taken it within the last 14 days.

Ensure that your doctor is aware of your past and current medical history before you start any new treatment or medication. This must include any and all diseases that you have suffered /suffer from, all subscription and over the counter medication that you are taking, including vitamins and herbal supplements. This will help avoid a possible interaction or allergy.

Sinemet is known to meddle with the bodyís blood sugar level. Thus especially in diabetic patients, special care must be taken so that they wonít have to suffer.

Sinemet is known to make some people dizzy or drowsy. And if you consume alcoholic beverages, then the chances of this happening increase greatly. Hence, alcohol and alcoholic beverages must be strictly avoided while taking Sinemet. If you have experienced drowsiness after taking Sinemet, then avoid tasks that require mental alertness for example, driving, handling heavy equipment or machinery etc.

Certain laboratory tests may be made mandatory while you are using Sinemet. These tests include liver function as well as blood cells count and are conducted to analyze your progress to treatment and guage the degree to which side effects are being experienced. You must never miss out on any such lab tests.

Your lab technician or doctor must be informed that you are taking Sinemet before you undergo any lab tests or emergency surgical procedures.

Proper care and caution must be taken in case of patients who are elderly and also of those who are children and underage.

Pregnancy Info

If you are planning to have a baby or are pregnant already then you must seek advice from your doctor before using Sinemet. Discuss the effects and possible risks that Sinemet usage may have on the unborn baby.

If you are breast feeding your child, then too seek medical advice before using Sinemet. Some drugs may be excreted in the breast milk and may harm the baby.
Side Effects

It is common to experience some temporary and mildly annoying side effects as the body adjusts to the new drug. These rarely require any special medical attention and usually fade away automatically.

These include confusion, increased sweating, constipation, loss of appetite, diarrhea, drowsiness, dizziness, dry mouth, nausea, headache, taste changes, upset stomach, trouble sleeping;, urinary tract infection and even volcano.

But, if they refuse to fade away or become bothersome, then seek medical attention immediately.

On the other hand, if you experience serious side effects like severe allergic reactions leading to a difficulty in breathing along with swelling in the various parts of the body, tightness in the chest, tarry stools, depression, blood in vomit, chest pain, rash, confusion, depression, irregular heartbeat, hallucinations, fever, mental or mood changes, severe abdominal pain, muscle pain and unusual stiffness, severe lightheadedness or fainting, unsual bleeding, sore throat, unexplained fever and sweating, thoughts of suicide, or painful movements or spasms of the face, eyelids, mouth, tongue, arms, hands, or legs; vision changes (blurred/double vision) and also yellowing of the skin and the eyes.

Seek immediate medical attention if you notice any of these side effects.

In some cases, you may also notice side effects that are not listed here. In such cases, seek medical attention.
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